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13 new genes for heart disease

An international scientific consortium which includes a hundred research centers announced the discovery of 13 new genes associated with risk for coronary artery pathology, namely the narrowing of the vessels that prevents the supply of oxygenated blood to the heart. The influence of most of these genes is independent of other known risk factors. With the discovery doubles the number of discovered genes that are related to heart disease. A total of 23 genes known to affect these conditions, only half a dozen may be related to risk factors like cholesterol or high blood pressure.

persentan the findings in three articles published in the journal Nature Genetics , which shows to what extent is a complex biological mechanism that leads to heart disease. Scientists have studied genetic samples 140,000 people of European descent that are unprecedented third heart enferemdad family, and the rest, forming the study's control group.

"The consortium has considered 10 times more samples than most research so far, so we have greatly increased power to detect small genetic variations," says Robert Roberts, University of Ottawa (Canada). "From now on our work must focus on understanding how these genes and develop new drugs to act on them and to identify the people who most benefit from reduced risk of heart attack and other heart problems.

Researchers have shown that up to 40% of coronary artery disease can be prevented by controlling cholesterol and blood pressure and avoiding the snuff and other harmful habits. The experts warn than half the risk of a heart attack due to genetic factors.

Source: http://www.elpais.com/articulo/sociedad/nuevos/genes/enfermedades/cardiacas/elpepusoccie/20110306elpepusoc_3/ Tes